Product Name : Camptothecin
Synonyms : Camptothecin ; 1H-Pyrano[34:6,7]indolizino[1,2-6]puinoline-3,14(4H,12H-)-dione,4-ethy1-4-hydroxy-(s)-
CAS No. : 7689-03-4
Mol. Formula : C20H16N2O4
Mol. Weight : 348.34
Botanical Source : Camptotheca acuminata Decne
Appearance : Light yellow needle-like crystal.
Purity : > 98% by HPLC
Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used as a cancer treatment in Traditional Chinese Medicine. CPT showed remarkable anticancer activity in preliminary clinical trials but also low solubility and (high) adverse drug reaction. Because of these disadvantages synthetic and medicinal chemists have developed numerous syntheses of Camptothecin and various derivatives to increase the benefits of the chemical, with good results. Two CPT analogues have been approved and are used in cancer chemotherapy today, topotecan and irinotecan.
Camptothecin could induce cell death in SMMC-7721, MCF-7, and HCT-116 tumor cells. Camptothecin has been reported to induce autophagy via AMPK-TSC2-mTOR pathway, at the mean time, induce premature senescence by ATM-Chk2-p53-p21 pathway.
Studies indicated that camptothecin had anti-tumor activity in (non-small cell lung cancer) NSCLC xenografts. Camptothecin -induced DNA damage has revealed to cause phosphorylation of H2AX (γH2AX). Previous studies have also demonstrated to reduce the expression of Top1 in cancer cells treated with camptothecins.
Read more:www.botanical-extracts.net
Synonyms : Camptothecin ; 1H-Pyrano[34:6,7]indolizino[1,2-6]puinoline-3,14(4H,12H-)-dione,4-ethy1-4-hydroxy-(s)-
CAS No. : 7689-03-4
Mol. Formula : C20H16N2O4
Mol. Weight : 348.34
Botanical Source : Camptotheca acuminata Decne
Appearance : Light yellow needle-like crystal.
Purity : > 98% by HPLC
Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used as a cancer treatment in Traditional Chinese Medicine. CPT showed remarkable anticancer activity in preliminary clinical trials but also low solubility and (high) adverse drug reaction. Because of these disadvantages synthetic and medicinal chemists have developed numerous syntheses of Camptothecin and various derivatives to increase the benefits of the chemical, with good results. Two CPT analogues have been approved and are used in cancer chemotherapy today, topotecan and irinotecan.
Camptothecin could induce cell death in SMMC-7721, MCF-7, and HCT-116 tumor cells. Camptothecin has been reported to induce autophagy via AMPK-TSC2-mTOR pathway, at the mean time, induce premature senescence by ATM-Chk2-p53-p21 pathway.
Studies indicated that camptothecin had anti-tumor activity in (non-small cell lung cancer) NSCLC xenografts. Camptothecin -induced DNA damage has revealed to cause phosphorylation of H2AX (γH2AX). Previous studies have also demonstrated to reduce the expression of Top1 in cancer cells treated with camptothecins.
Read more:www.botanical-extracts.net