Product name: Aprotinin
Synonym: Trypsin inhibitor (basic)
Application: A reversible serine protease blocking and binding agent
CAS Number: 9087-70-1
Molecular Weight: 6511.44
Molecular Formula: C284H432N84O79S7
Aprotinin, aswell accepted as bovine pancreatic trypsin inhibitor, BPTI is a protein, that is acclimated as medication administered by bang to abate bleeding during circuitous surgery, such as affection and alarmist surgery. Its capital aftereffect is the slowing down of fibrinolysis, the action that leads to the breakdown of claret clots. The aim in its use is to abatement the charge for claret transfusions during surgery, as able-bodied as end-organ accident due to hypotension (low claret pressure) as a aftereffect of apparent claret loss.
Aprotinin is a individual alternation polypeptide (58 amino-acids) crosslinked by three disulfide bridges, assuming aggressive and capricious inhibiton of proteolytic and esterolytic activity. Aprotinin forms abiding complexes and blocks the alive sites of serine protease enzymes. Binding is capricious with a lot of aprotinin-protease complexes dissociating at pH >10 or < 3 (optimum pH 5-7); able absorption is equimolar with protease. Acclimated as a proteolytic inhibitor in radioimmunoassays of polypeptide hormones.
Read more:http://www.orangeidc.com/
Synonym: Trypsin inhibitor (basic)
Application: A reversible serine protease blocking and binding agent
CAS Number: 9087-70-1
Molecular Weight: 6511.44
Molecular Formula: C284H432N84O79S7
Aprotinin, aswell accepted as bovine pancreatic trypsin inhibitor, BPTI is a protein, that is acclimated as medication administered by bang to abate bleeding during circuitous surgery, such as affection and alarmist surgery. Its capital aftereffect is the slowing down of fibrinolysis, the action that leads to the breakdown of claret clots. The aim in its use is to abatement the charge for claret transfusions during surgery, as able-bodied as end-organ accident due to hypotension (low claret pressure) as a aftereffect of apparent claret loss.
Aprotinin is a individual alternation polypeptide (58 amino-acids) crosslinked by three disulfide bridges, assuming aggressive and capricious inhibiton of proteolytic and esterolytic activity. Aprotinin forms abiding complexes and blocks the alive sites of serine protease enzymes. Binding is capricious with a lot of aprotinin-protease complexes dissociating at pH >10 or < 3 (optimum pH 5-7); able absorption is equimolar with protease. Acclimated as a proteolytic inhibitor in radioimmunoassays of polypeptide hormones.
Read more:http://www.orangeidc.com/